AOD 9604

Description

AOD9604 is a synthetic peptide fragment derived from the C-terminal region of human growth hormone (amino acids 176–191). It has become a subject of scientific interest due to its potential involvement in pathways related to metabolism, lipid utilisation, and body composition.

Unlike full-length growth hormone, AOD9604 was developed to investigate whether specific metabolic effects could be separated from the broader hormonal actions of growth hormone. Early preclinical and clinical studies explored its potential role in fat metabolism and energy regulation, leading to continued interest within the research community.

Research Highlights

• Preclinical studies have reported that AOD9604 may influence lipolysis (the breakdown of stored fat) and inhibit lipogenesis (the formation of new fat cells).
• Human studies have investigated AOD9604 in the context of body composition and weight management, with researchers evaluating its safety profile and metabolic effects.
• Research has suggested that AOD9604 does not appear to significantly affect blood glucose levels or stimulate insulin-like growth factor-1 (IGF-1) production in the same manner as full growth hormone.

References

1. Ng FM, et al. Effects of human growth hormone fragment 176-191 in obese subjects. Obesity Research. 2001;9(7):419-429.
2. Heffernan MA, et al. A lipolytic fragment of human growth hormone. Endocrinology. 2001;142(12):5184-5190.
3. Kozka IJ, et al. The effect of a human growth hormone fragment (AOD9604) on lipid metabolism in rodents. International Journal of Obesity. 2003;27(2):220-226.