MOTS-c

Description

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring mitochondrial-derived peptide encoded within mitochondrial DNA. It has become an important subject of scientific research due to its involvement in cellular metabolism, energy homeostasis, and metabolic adaptation.

Researchers have investigated MOTS-c in preclinical and early clinical studies to better understand its influence on glucose metabolism, insulin sensitivity, exercise physiology, and healthy ageing. As a signalling peptide linking mitochondrial function with nuclear gene expression, MOTS-c continues to attract interest in research exploring metabolic health and cellular resilience.

Areas of Scientific Interest

• Research has investigated MOTS-c for its potential role in regulating glucose metabolism and maintaining metabolic homeostasis.
• Experimental studies have explored its influence on cellular energy production, mitochondrial signalling, and metabolic adaptation during physical activity.
• Researchers have examined MOTS-c in studies involving insulin sensitivity, skeletal muscle physiology, and age-related metabolic function.
• Ongoing investigations continue to evaluate the role of mitochondrial-derived peptides in exercise physiology, cellular stress responses, and healthy ageing.

Product Features

• High-purity lyophilised peptide
• Contains 10mg MOTS-c
• Manufactured for laboratory and scientific research
• Quality tested for identity and purity
• Securely packaged to help maintain product integrity

References

• Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. 2015.
• Kim KH, Son JM, Benayoun BA, Lee C. The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate adaptive gene expression in response to metabolic stress. Cell Metabolism. 2018.
• Reynolds JC, Lai RW, Woodhead JST, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications. 2021.